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The requests from the XI machine could be getting natted and appear to be coming from a different IP address. In which case you'll want to edit the nsclient.ini or nrpe.cfg and update the allowed_hosts or "allowed host" configurations to allow it. You could also check /var/log/messages or nsclient.log on the remote machine to see if it gives any more detail as to why the connection is refused.
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root@monitor:/usr/lib/nagios/plugins$ ./check_nrpe -H 89.160.16.2
CHECK_NRPE: Error - Could not complete SSL handshake.
root@monitor:/usr/lib/nagios/plugins$ ./check_nrpe -H 89.160.16.2 -pxxxx
Connection refused by host
Out env is little complicated though, we have a proxy that handles server to server communication and apart from it user to server, restricting access for a user to access a specific server, but accepting access for a server to communicate with another...